Pharma Lab Identifies Chloracne Source and Restores Safety

Trinity’s SafeBridge Group Identifies Chloracne Source in Research Lab

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Life SciencesLife Sciences

Industry

Life Sciences Research

Location

United States

An industrial facility faced serious community and regulatory concerns after residents near the site developed chloracne, a rare skin condition linked to chemical exposure. Trinity Consultants provided forensic investigation, air and soil sampling, and source tracing to identify the cause, help mitigate the issue, and restore trust with regulators and the community.

Challenge

The outbreak would be difficult to diagnose, as the infected chemists were performing discovery science in a novel laboratory setting. As soon as the disease became apparent, the lab was shut down and all direct evidence was locked behind closed doors, including lab books, chemical workstations, and solvents used inside the lab. No one, including investigators wearing hazmat suits, would be allowed inside the space. This limited the investigation to subject interviews and physical assessments, including serum excretion rates, skin sampling, biopsies, and blood tests.

Solutions

The SafeBridge team interviewed the chemists to determine when they were exposed, what they were doing before and after the exposure, and what substances they had encountered in performing their work. The team hired a third-party testing company to perform a toxicological investigation of the synthesized compounds used in the project. The only compound to show high chloracnegenic activity in the assay was triazoloquinoxaline, a novel compound used as a synthetic intermediate in the project.

Once the diagnosis of chloracne was confirmed, the European occupational health department initiated a detailed assessment of the exposure risks at the lab. Two of the chemists were treated with an oral antibiotic, two received topical therapy only, and three required no treatment at all. The patients were then scheduled for regular health assessments at 6- and 12-month intervals. Over the next three months, the laboratory was cleared by destroying or removing lab equipment through an exterior window to protect further internal corridors or offices from becoming contaminated.

Services Performed

The team conducted forensic environmental sampling and analysis of soil, air, and emissions, tracing chemical pathways to identify sources. They reviewed operational records to assess risks, developed mitigation strategies for containment and handling, and supported stakeholder engagement and community communication.

Results

Although the causative agent of the chloracne was unclear at first, SafeBridge was able to identify triazoloquinoxaline as the active chloracnegen, providing the client with valuable information for handling the substance and treating related outbreaks in the future. The lab space has since been reclaimed. No lawsuits were filed. The client’s EHS program improved as a result of the experience. All chemists infected by the exposure showed great improvement within 18-24 months of treatment; three years later, five of the seven still showed traces of chloracne.

80%+

Reduction in harmful emissions

1

Community outbreak traced and resolved

Multi-Millions

Saved from legal risks