Life Sciences
Process Design
The Advent Engineering team, part of Trinity Consultants, provides comprehensive design and engineering support for manufacturing facilities in the life science sector.
Experts in manufacturing processes at the clinical and commercial phase, Trinity’s Advent Engineering team provides customized design solutions for the entire engineering life cycle, including feasibility design, conceptual design, basic design, and detailed design. Our design teams include process subject matter experts with extensive professional credentials including chemical and mechanical professional engineering licenses, operational excellence, and leaders in ASME and ISPE. Our distinct competitive advantage is our team’s direct practical experience with a wide array of processes, which equips us with a full-spectrum view of the challenges and opportunities presented to clients within R&D and manufacturing settings.
Holistic Solutions to Process Design Challenges
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Related Services
Process Development
Expert support for process and product development for clinical and commercial GMP processing.
Project Management
Integrated project management services for pharmaceutical and biopharmaceutical sectors.
Commissioning, Qualification and Validation (CQV)
Prompt, knowledgeable CQV support for bio-pharma GMP manufacturing.Our Results
Featured Projects
Biotech Company Scales and Commercializes Manufacturing in Record Time
Advent enabled a biotech company to successfully complete technology transfer, while demonstrating comparability of process and product, in record time and within budget.
Advent Enables Manufacturing Flexibility for Biopharma Leader
Advent enabled a biopharma leader to position its manufacturing lines for greater flexibility for vaccine production, identifying opportunities to streamline to complete testing, commissioning and qualifying processes in a single month.
BioPharma Leader Scales Up Bioreactors Quickly and Cost-Effectively
Using computational fluid dynamics modeling (CFD) to simulate the fluid dynamics and working parts of a bioreactor, Advent enabled its client to optimize the design of bioreactors before they were built, mitigating risk and improving speed to market.Service Specifics
Process Design
Process Design Services
- Equipment design, sizing, specifications, and procurement
- Process skid design
- Design drawings (PFD, P&ID, GA, Piping) and schematics
- Instrumentation selection
- Scale-up and Scale-down
- Thermal/fluid dynamics analyses
- Fluid/flow simulation (CFD analysis)
- 3-D modeling (AutoCAD, SolidWorks)
- Process simulation/modeling (e.g. Superpro, SchedulePro)
- Process analytical technology
- Hydrodynamic characteristics
- Statistical analysis (MATLAB, JMP)
Processes
Clients routinely depend on our expertise and customized solutions, from solving design challenges and authoring design documents, to overseeing implementation, across a broad range of processes from small scale to full-scale cGMP manufacturing. These include:
- Upstream process (cell culture, fermentation)
- Downstream separation processes (filtration, chromatography, centrifugation, TFF)
- Solution prep systems (buffer/media fixed and portable vessels)
- Sterilizers and part washers
- Formulation & fill-finish
- Clean and plant utilities
- Single use technologies
- CIP / SIP/ VHP
- HVAC & facility design